In my previous post I mentioned that Natty is now working with Wubi (on the current daily-live image), and also that the new Unity desktop is now working on my old Dell with an ATI X1300 Radeon (whereas with 10.10 netbook edition and early Natty Alphas, Unity did not work at all).
Since then I've reinstalled a number of times and I'm coming to like Natty and Unity. It feels - well - "natty". Not that that's a word I'd use frequently and I consider it only marginally better than the upcoming Oneiric Ocelot (that must be some good weed over at Canonical).
The only Wubi issues I've found are a couple of boot problems with the latest version of Grub. The first was fixed very quickly, and the second only seems to affect my installs when they're not on the main Windows partition. I've worked around this by manually booting and then editing grub.cfg by hand. I believe that it's basically the same grub rebooting issue from 10.04 and upgrades to 10.10, but this time there is no workaround - other than changing the 00_header script in /etc/grub.d/ but hopefully this will be resolved before release.
The more people that test and report bugs, the better. So if you decide to try Natty on Wubi, please report any bugs you find in launchpad.net and make it better for newcomers to Ubuntu.